Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers

Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical. Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates to fill such a role, but their challenging synthesis limits...

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Main Authors: Li, Chengxi (Author), Callahan, Alex J. (Author), Simon, Mark (Author), Totaro, Kyle A. (Author), Mijalis, Alexander James (Author), Phadke, Kruttika-Suhas (Author), Zhang, Genwei (Author), Hartrampf, Nina (Author), Schissel, Carly K. (Author), Zhou, Ming (Author), Zong, Hong (Author), Hanson, Gunnar J. (Author), Loas, Andrei Ioan (Author), Pohl, Nicola L. B. (Author), Verhoeven, David E. (Author), Pentelute, Bradley L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2021-08-09T22:25:20Z.
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