Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

Abstract Background Aspartate biosynthesis and its delivery to the cytosol can be crucial for tumor growth in vivo. However, the impact of intracellular aspartate levels on metastasis has not been studied. We previously described that loss-of-aspartate glutamate carrier 1 (SLC25A12 or AGC1), an impo...

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Main Authors: Alkan, H. Furkan (Author), Vesely, Paul W (Author), Hackl, Hubert (Author), Foßelteder, Johannes (Author), Schmidt, Daniel (Author), Vander Heiden, Matthew G. (Author), Pichler, Martin (Author), Hoefler, Gerald (Author), Bogner-Strauss, Juliane G (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: BioMed Central, 2022-07-15T19:34:57Z.
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