Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

Bacterial sepsis and severe COVID-19 share similar clinical manifestations and are both associated with dysregulation of the myeloid cell compartment. We previously reported an expanded CD14⁺ monocyte state, MS1, in patients with bacterial sepsis and validated expansion of this cell subpopulation in...

Full description

Bibliographic Details
Main Authors: Reyes, Miguel (Author), Filbin, Michael R. (Author), Bhattacharyya, Roby P. (Author), Sonny, Abraham (Author), Mehta, Arnav (Author), Billman, Kianna (Author), Kays, Kyle R. (Author), Pinilla-Vera, Mayra (Author), Benson, Maura E. (Author), Cosimi, Lisa A. (Author), Hung, Deborah T. (Author), Levy, Bruce D. (Author), Villani, Alexandra-Chloe (Author), Sade-Feldman, Moshe (Author), Baron, Rebecca M. (Author), Goldberg, Marcia B. (Author), Blainey, Paul C (Author), Hacohen, Nir (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2021-09-24T18:11:41Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items