Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles

Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles

The oncogenic transcription factor STAT3 is aberrantly activated in 70% of breast cancers, including nearly all triple-negative breast cancers (TNBCs). Because STAT3 is difficult to target directly, we considered whether metabolic changes driven by activated STAT3 could provide a therapeutic opportu...

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Bibliographic Details
Main Authors: Tošić, Isidora (Author), Heppler, Lisa N (Author), Egusquiaguirre, Susana P (Author), Boehnke, Natalie (Author), Correa, Santiago (Author), Costa, Daniel F (Author), Moore, Elizabeth A Grossman (Author), Pal, Sharmistha (Author), Richardson, Douglas S (Author), Ivanov, Alexander R (Author), Haas-Kogan, Daphne A (Author), Nomura, Daniel K (Author), Hammond, Paula T (Author), Frank, David A (Author)
Format: Article
Language:English
Published: American Association for Cancer Research (AACR), 2021-10-04T18:23:32Z.
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