Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints

© 2020, The Author(s). In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhances a pre-existing syntheti...

Full description

Bibliographic Details
Main Authors: Kong, Yi Wen (Author), Dreaden, Erik C (Author), Morandell, Sandra (Author), Zhou, Wen (Author), Dhara, Sanjeev S (Author), Sriram, Ganapathy (Author), Lam, Fred C (Author), Patterson, Jesse C (Author), Quadir, Mohiuddin (Author), Dinh, Anh (Author), Shopsowitz, Kevin E (Author), Varmeh, Shohreh (Author), Yilmaz, Ömer H (Author), Lippard, Stephen J (Author), Reinhardt, H Christian (Author), Hemann, Michael T (Author), Hammond, Paula T (Author), Yaffe, Michael B (Author)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2021-10-25T17:00:12Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items