Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
© 2020, The Author(s). In response to DNA damage, a synthetic lethal relationship exists between the cell cycle checkpoint kinase MK2 and the tumor suppressor p53. Here, we describe the concept of augmented synthetic lethality (ASL): depletion of a third gene product enhances a pre-existing syntheti...
Main Authors: | Kong, Yi Wen (Author), Dreaden, Erik C (Author), Morandell, Sandra (Author), Zhou, Wen (Author), Dhara, Sanjeev S (Author), Sriram, Ganapathy (Author), Lam, Fred C (Author), Patterson, Jesse C (Author), Quadir, Mohiuddin (Author), Dinh, Anh (Author), Shopsowitz, Kevin E (Author), Varmeh, Shohreh (Author), Yilmaz, Ömer H (Author), Lippard, Stephen J (Author), Reinhardt, H Christian (Author), Hemann, Michael T (Author), Hammond, Paula T (Author), Yaffe, Michael B (Author) |
---|---|
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC,
2021-10-25T17:00:12Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints
by: Yi Wen Kong, et al.
Published: (2020-08-01) -
Exploiting synthetic lethal interactions for targeted cancer therapy
by: Reinhardt, H. Christian, et al.
Published: (2012) -
A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo
by: Reinhardt, H. Christian, et al.
Published: (2014) -
A Reversible Gene-Targeting Strategy Identifies Synthetic Lethal Interactions between MK2 and p53 in the DNA Damage Response In Vivo
by: Sandra Morandell, et al.
Published: (2013-11-01) -
Polymer conjugated retinoids for controlled transdermal delivery
by: Castleberry, Steven A, et al.
Published: (2019)