A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies

A participant-derived xenograft model of HIV enables long-term evaluation of autologous immunotherapies

<jats:p>HIV-specific CD8+ T cells partially control viral replication and delay disease progression, but they rarely provide lasting protection, largely due to immune escape. Here, we show that engrafting mice with memory CD4+ T cells from HIV+ donors uniquely allows for the in vivo evaluation...

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Main Authors: McCann, Chase D (Author), van Dorp, Christiaan H (Author), Danesh, Ali (Author), Ward, Adam R (Author), Dilling, Thomas R (Author), Mota, Talia M (Author), Zale, Elizabeth (Author), Stevenson, Eva M (Author), Patel, Shabnum (Author), Brumme, Chanson J (Author), Dong, Winnie (Author), Jones, Douglas S (Author), Andresen, Thomas L (Author), Walker, Bruce D (Author), Brumme, Zabrina L (Author), Bollard, Catherine M (Author), Perelson, Alan S (Author), Irvine, Darrell J (Author), Jones, R Brad (Author)
Format: Article
Language:English
Published: Rockefeller University Press, 2021-10-25T18:31:21Z.
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