Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Abstract Background Vaccines comprising recombinant subunit proteins are well-suited to low-cost and high-volume production for global use. The design of manufacturing processes to produce subunit vaccines depends, however, on the inherent biophysical traits presented by an individual antigen of int...

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Main Authors: Dalvie, Neil C (Author), Brady, Joseph R (Author), Crowell, Laura E (Author), Tracey, Mary K (Author), Biedermann, Andrew M (Author), Kaur, Kawaljit (Author), Hickey, John M (Author), Kristensen, D. L (Author), Bonnyman, Alexandra D (Author), Rodriguez-Aponte, Sergio A (Author), Whittaker, Charles A (Author), Bok, Marina (Author), Vega, Celina (Author), Mukhopadhyay, Tarit K (Author), Joshi, Sangeeta B (Author), Volkin, David B (Author)
Format: Article
Language:English
Published: BioMed Central, 2021-11-01T14:33:19Z.
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