Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

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Copyright © 2020 The Authors, some rights reserved. Fragile X syndrome is caused by FMR1 gene silencing and loss of the encoded fragile X mental retardation protein (FMRP), which binds to mRNA and regulates translation. Studies in the Fmr1-/y mouse model of fragile X syndrome indicate that aberrant...

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Main Authors: McCamphill, Patrick K. (Author), Stoppel, Laura J. (Author), Senter, Rebecca K. (Author), Lewis, Michael C. (Author), Heynen, Arnold J. (Author), Stoppel, David C. (Author), Sridhar, Vinay (Author), Collins, Katie A. (Author), Shi, Xi (Author), Pan, Jen Q. (Author), Madison, Jon (Author), Cottrell, Jeffrey R. (Author), Huber, Kimberly M. (Author), Scolnick, Edward M. (Author), Holson, Edward B. (Author), Wagner, Florence F. (Author), Bear, Mark F. (Author)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2022-03-14T18:03:06Z.
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