Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains

© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer's disease. We conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (H3K9ac) mark in 669 aged human prefro...

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Main Authors: Klein, Hans-Ulrich (Author), McCabe, Cristin (Author), Gjoneska, Elizabeta (Author), Sullivan, Sarah E (Author), Kaskow, Belinda J (Author), Tang, Anna (Author), Smith, Robert V (Author), Xu, Jishu (Author), Pfenning, Andreas R (Author), Bernstein, Bradley E (Author), Meissner, Alexander (Author), Schneider, Julie A (Author), Mostafavi, Sara (Author), Tsai, Li-Huei (Author), Young-Pearse, Tracy L (Author), Bennett, David A (Author), De Jager, Philip L (Author)
Format: Article
Language:English
Published: Springer Nature, 2021-12-06T19:49:21Z.
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