Highly Parallel Profiling of Cas9 Variant Specificity
© 2020 Elsevier Inc. Schmid-Burgk et al. develop tagmentation-based tag integration site sequencing (TTISS), a rapid, streamlined protocol for analyzing double-strand breaks such as those created by CRISPR nucleases. Using TTISS, they comprehensively assess Cas9 variants, revealing a trade-off betwe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier BV,
2021-12-08T18:21:07Z.
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| Subjects: | |
| Online Access: | Get fulltext |