Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

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Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling are poorly understood. Here, we demonstrate that hepcidin is activated ectopically in CRC. Mice deficient in hepcidin specifically in the colon tumour epithelium, compared wit...

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Main Authors: Schwartz, Andrew J (Author), Goyert, Joshua W (Author), Solanki, Sumeet (Author), Kerk, Samuel A (Author), Chen, Brandon (Author), Castillo, Cristina (Author), Hsu, Peggy P (Author), Do, Brian T (Author), Singhal, Rashi (Author), Dame, Michael K (Author), Lee, Ho-Joon (Author), Spence, Jason R (Author), Lakhal-Littleton, Samira (Author), Heiden, Matthew G Vander (Author), Lyssiotis, Costas A (Author), Xue, Xiang (Author), Shah, Yatrik M (Author)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2022-01-04T19:35:24Z.
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