Local Targeting of NAD + Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma

Local Targeting of NAD + Salvage Pathway Alters the Immune Tumor Microenvironment and Enhances Checkpoint Immunotherapy in Glioblastoma

© 2020 American Association for Cancer Research. The aggressive primary brain tumor glioblastoma (GBM) is characterized by aberrant metabolism that fuels its malignant phenotype. Diverse genetic subtypes of malignant glioma are sensitive to selective inhibition of the NAD+ salvage pathway enzyme nic...

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Main Authors: Li, Ming (Author), Kirtane, Ameya R (Author), Kiyokawa, Juri (Author), Nagashima, Hiroaki (Author), Lopes, Aaron (Author), Tirmizi, Zain A (Author), Lee, Christine K (Author), Traverso, Giovanni (Author), Cahill, Daniel P (Author), Wakimoto, Hiroaki (Author)
Format: Article
Language:English
Published: American Association for Cancer Research (AACR), 2022-01-28T14:13:00Z.
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