Modeling of copy number variability in Pichia pastoris
Development of continuous biopharmaceutical manufacturing processes is an area of active research. This study considers the long-term transgene copy number stability of Pichia pastoris in continuous bioreactors. We propose a model of copy number loss that quantifies population heterogeneity. An anal...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley,
2022-02-16T19:04:32Z.
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| Subjects: | |
| Online Access: | Get fulltext |