Two-Step Synthesis of α-Aryl-α-diazoamides as Modular Bioreversible Labels
α-Aryl-α-diazoamides were synthesized in two steps under mild conditions. This expeditious route employs Pd-catalyzed C-H arylation of N-succinimidyl 2-diazoacetate to obtain N-succinimidyl 2-aryl-2-diazoacetates, followed by aminolysis. The ensuing diazo compounds can esterify carboxyl groups in aq...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2022-03-17T14:22:13Z.
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| Subjects: | |
| Online Access: | Get fulltext |