PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis

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PNC-27, a 32-residue peptide that contains an HDM-2 binding domain and a cell-penetrating peptide (CPP) leader sequence kills cancer, but not normal, cells by binding to HDM-2 associated with the plasma membrane and induces the formation of pores causing tumor cell lysis and necrosis. Conformational...

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Main Authors: Sarafraz-Yazdi, Ehsan (Author), Mumin, Stephen (Author), Cheung, Diana (Author), Fridman, Daniel (Author), Lin, Brian (Author), Wong, Lawrence (Author), Rosal, Ramon (Author), Rudolph, Rebecca (Author), Frenkel, Matthew (Author), Thadi, Anusha (Author), Morano, William F. (Author), Bowne, Wilbur B. (Author), Pincus, Matthew R. (Author), Michl, Josef (Author)
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute, 2022-04-25T12:35:01Z.
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