Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

A general approach for heritably altering gene expression has the potential to enable many discovery and therapeutic efforts. Here, we present CRISPRoff-a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone mod...

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Main Authors: Nuñez, James K (Author), Chen, Jin (Author), Pommier, Greg C (Author), Cogan, J Zachery (Author), Replogle, Joseph M (Author), Adriaens, Carmen (Author), Ramadoss, Gokul N (Author), Shi, Quanming (Author), Hung, King L (Author), Samelson, Avi J (Author), Pogson, Angela N (Author), Kim, James YS (Author), Chung, Amanda (Author), Leonetti, Manuel D (Author), Chang, Howard Y (Author), Kampmann, Martin (Author), Bernstein, Bradley E (Author), Hovestadt, Volker (Author), Gilbert, Luke A (Author), Weissman, Jonathan S (Author)
Format: Article
Language:English
Published: Elsevier BV, 2022-05-16T19:25:37Z.
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