Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

We examined how baseline CD4+ T cell repertoire and precursor states impact responses to pathogen infection in humans using primary immunization with yellow fever virus (YFV) vaccine. YFV-specific T cells in unexposed individuals were identified by peptide-MHC tetramer staining and tracked pre- and...

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Main Authors: Pan, Yi-Gen (Author), Aiamkitsumrit, Benjamas (Author), Bartolo, Laurent (Author), Wang, Yifeng (Author), Lavery, Criswell (Author), Marc, Adam (Author), Holec, Patrick V (Author), Rappazzo, C Garrett (Author), Eilola, Theresa (Author), Gimotty, Phyllis A (Author), Hensley, Scott E (Author), Antia, Rustom (Author), Zarnitsyna, Veronika I (Author), Birnbaum, Michael E (Author), Su, Laura F (Author)
Format: Article
Language:English
Published: Elsevier BV, 2022-06-15T17:20:31Z.
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