BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
<jats:p> BACE-1 is required for generating β-amyloid (Aβ) peptides in Alzheimer's disease (AD). Here, we report that microglial BACE-1 regulates the transition of homeostatic to stage 1 disease-associated microglia (DAM-1) signature. BACE-1 deficiency elevated levels of transcription fact...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS),
2022-07-13T16:40:04Z.
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| Subjects: | |
| Online Access: | Get fulltext |