Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system
Abstract Background Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) coculture model to study the role of mechanical injury and...
Main Authors: | Dwivedi, Garima (Author), Flaman, Lisa (Author), Alaybeyoglu, Begum (Author), Struglics, André (Author), Frank, Eliot H. (Author), Chubinskya, Susan (Author), Trippel, Stephen B. (Author), Rosen, Vicki (Author), Cirit, Murat (Author), Grodzinsky, Alan J. (Author) |
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Format: | Article |
Language: | English |
Published: |
BioMed Central,
2022-08-22T13:04:15Z.
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Subjects: | |
Online Access: | Get fulltext |
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