Bifunctional polymeric inhibitors of human influenza A viruses

Bifunctional polymeric inhibitors of human influenza A viruses

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Purpose. New antiviral agents were prepared by attaching derivatives of sialic acid (1) and of the drug zanamivir (2) to poly(isobutylene-alt-maleic anhydride) (poly-(1 + 2)) or by mixing poly-1 and poly-2, followed by assaying them against wild-type and drug-resistant influenza A Wuhan viruses. Met...

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Main Authors: Haldar, Jayanta (Contributor), Alvarez de Cienfuegos, Luis (Contributor), Tumpey, Terrence M. (Author), Gubareva, Larisa V. (Author), Chen, Jianzhu (Contributor), Klibanov, Alexander M. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Klibanov, Alexander M (Contributor)
Format: Article
Language:English
Published: Springer Netherlands, 2009-11-19T20:57:13Z.
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