Thymic Selection of T-Cell Receptors as an Extreme Value Problem

Thymic Selection of T-Cell Receptors as an Extreme Value Problem

T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on anti...

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Bibliographic Details
Main Authors: Kardar, Mehran (Contributor), Chakraborty, Arup K. (Contributor), Shaknovich, Eugene I. (Author), Kosmrlj, Andrej (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor)
Format: Article
Language:English
Published: American Physical Society, 2010-02-17T16:31:24Z.
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