Thymic Selection of T-Cell Receptors as an Extreme Value Problem
T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on anti...
Main Authors: | , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
American Physical Society,
2010-02-17T16:31:24Z.
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Subjects: | |
Online Access: | Get fulltext |
Summary: | T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions). National Institutes of Health |
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