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01769 am a22002893u 4500 |
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51770 |
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|a dc
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|a Kardar, Mehran
|e author
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|a Massachusetts Institute of Technology. Department of Biological Engineering
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Massachusetts Institute of Technology. Department of Physics
|e contributor
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|a Chakraborty, Arup K.
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|a Kosmrlj, Andrej
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|a Kardar, Mehran
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|a Chakraborty, Arup K.
|e contributor
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|a Chakraborty, Arup K.
|e author
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|a Shaknovich, Eugene I.
|e author
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|a Kosmrlj, Andrej
|e author
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|a Thymic Selection of T-Cell Receptors as an Extreme Value Problem
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|b American Physical Society,
|c 2010-02-17T16:31:24Z.
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| 856 |
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|z Get fulltext
|u http://hdl.handle.net/1721.1/51770
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|a T lymphocytes (T cells) orchestrate adaptive immune responses upon activation. T-cell activation requires sufficiently strong binding of T-cell receptors on their surface to short peptides (p) derived from foreign proteins, which are bound to major histocompatibility gene products (displayed on antigen-presenting cells). A diverse and self-tolerant T-cell repertoire is selected in the thymus. We map thymic selection processes to an extreme value problem and provide an analytic expression for the amino acid compositions of selected T-cell receptors (which enable its recognition functions).
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|a National Institutes of Health
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|a en_US
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|a Article
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|t Physical Review Letters
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