Fuzzy Logic Analysis of Kinase Pathway Crosstalk in TNF/EGF/Insulin-Induced Signaling

When modeling cell signaling networks, a balance must be struck between mechanistic detail and ease of interpretation. In this paper we apply a fuzzy logic framework to the analysis of a large, systematic dataset describing the dynamics of cell signaling downstream of TNF, EGF, and insulin receptors...

Full description

Bibliographic Details
Main Authors: Aldridge, Bree B. (Contributor), Saez-Rodriguez, Julio (Contributor), Muhlich, Jeremy L. (Author), Sorger, Peter K. (Contributor), Lauffenburger, Douglas A. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-03-12T15:55:24Z.
Subjects:
Online Access:Get fulltext