Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

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Animal cells initiate cytokinesis in parallel with anaphase onset, when an actomyosin ring assembles and constricts through localized activation of the small GTPase RhoA, giving rise to a cleavage furrow. Furrow formation relies on positional cues provided by anaphase spindle microtubules (MTs), but...

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Main Authors: Burkard, Mark E. (Author), Maciejowski, John (Author), Rodriguez-Bravo, Veronic (Author), Repka, Michael (Author), Lowery, Drew M. (Contributor), Clauser, Karl R. (Contributor), Shokat, Kevan M. (Author), Jallepalli, Prasad V. (Author), Zhang, Chao, Ph. D. Massachusetts Institute of Technology (Author), Carr, Steven A (Author), Yaffe, Michael B (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Yaffe, Michael B. (Contributor), Carr, Steven A. (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-03-12T16:45:16Z.
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