Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4

Ectopic expression of defined transcription factors can reprogram somatic cells to induced pluripotent stem (iPS) cells, but the utility of iPS cells is hampered by the use of viral delivery systems. Small molecules offer an alternative to replace virally transduced transcription factors with chemic...

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Main Authors: Hanna, Jacob (Contributor), Markoulaki, Styliani (Contributor), Mathur, Divya (Contributor), Staerk, Judith (Contributor), Foreman, Ruth K. (Contributor), Jaenisch, Rudolf (Contributor), Schultz, Peter G. (Author), Cho, Charles Y. (Author), Brinker, Achim (Author), Kunick, Conrad (Author), Bollong, Michael (Author), Bouchez, Laure C. (Author), Charette, Bradley D. (Author), Lairson, Luke L. (Author), Garcia, Michael (Author), Lyssiotis, Costas A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: United States National Academy of Sciences, 2010-03-12T21:09:29Z.
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