Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

Loss of Hsp70 Exacerbates Pathogenesis But Not Levels of Fibrillar Aggregates in a Mouse Model of Huntington's Disease

Endogenous protein quality control machinery has long been suspected of influencing the onset and progression of neurodegenerative diseases characterized by accumulation of misfolded proteins. Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of a polyglutam...

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Main Authors: Lindquist, Susan (Contributor), Steele, Andrew D. (Contributor), Wacker, Jennifer L. (Author), Huang, Shao-Yi (Author), Aron, Rebecca (Author), Lotz, Gregor P. (Author), Nguyen, QuangVu (Author), Giorgini, Flaviano (Author), Roberson, Erik D. (Author), Masliah, Eliezer (Author), Muchowski, Paul J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Society for Neuroscience, 2010-07-15T14:07:25Z.
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