A model for genetic and epigenetic regulatory networks identifies rare for transcription factor induced pluripotency

With relatively low efficiency, differentiated cells can be reprogrammed to a pluripotent state by ectopic expression of a few transcription factors. An understanding of the mechanisms that underlie data emerging from such experiments can help design optimal strategies for creating pluripotent cells...

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Bibliographic Details
Main Authors: Artyomov, Maxim N. (Contributor), Meissner, Alexander (Author), Chakraborty, Arup K. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-08-27T14:16:35Z.
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