Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Optimization of Duplex Stability and Terminal Asymmetry for shRNA Design

Prediction of efficient oligonucleotides for RNA interference presents a serious challenge, especially for the development of genome-wide RNAi libraries which encounter difficulties and limitations due to ambiguities in the results and the requirement for significant computational resources. Here we...

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Bibliographic Details
Main Authors: Spiridonov, Alexey Nikolaevich (Contributor), Matveeva, Olga V. (Author), Kang, Yibin (Author), Sætrom, Pål (Author), Nemtsov, Vladimir A. (Author), Ogurtsov, Aleksey Y. (Author), Nechipurenko, Yury D. (Author), Shabalina, Svetlana A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Mathematics (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2010-08-27T15:10:43Z.
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