A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase

A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase

The only Y-family DNA polymerase conserved among all domains of life, DinB and its mammalian ortholog pol κ, catalyzes proficient bypass of damaged DNA in translesion synthesis (TLS). Y-family DNA polymerases, including DinB, have been implicated in diverse biological phenomena ranging from adaptive...

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Bibliographic Details
Main Authors: Walker, Graham C. (Contributor), Jarosz, Daniel F. (Contributor), Delaney, James C. (Contributor), Essigmann, John M. (Contributor), Cohen, Susan E., Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Cohen, Susan E. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-03-01T23:48:05Z.
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