Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors.1 To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carrier...

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Main Authors: Green, Todd (Contributor), Guiducci, Candace (Contributor), Segre, Ayellet V. (Contributor), Daly, Mark J. (Contributor), Altshuler, David (Contributor), Korn, Joshua M. (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Korn, Joshua Marc (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-06-15T20:45:30Z.
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