Highly Effective Gene Transfection In Vivo by Alkylated Polyethylenimine
We mechanistically explored the effect of increased hydrophobicity of the polycation on the efficacy and specificity of gene delivery in mice. N-Alkylated linear PEIs with varying alkyl chain lengths and extent of substitution were synthesized and characterized by biophysical methods. Their in vivo...
Main Authors: | , , |
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Other Authors: | , , |
Format: | Article |
Language: | English |
Published: |
Hindawi Pub. Corp.,
2011-07-13T19:01:44Z.
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Subjects: | |
Online Access: | Get fulltext |