Profilin1 regulates PI(3,4)P-2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells
Profilin1, a ubiquitously expressed actin-binding protein, plays a critical role in cell migration through actin cytoskeletal regulation. Given the traditional view of profilin1 as a promigratory molecule, it is difficult to reconcile observations that profilin1 is down-regulated in various invasive...
Main Authors: | Bae, Yong Ho (Author), Ding, Zhijie (Author), Das, Tuhin (Author), Wells, Alan (Author), Gertler, Frank (Contributor), Roy, Partha (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2011-07-22T17:03:08Z.
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Subjects: | |
Online Access: | Get fulltext |
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