Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations

Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations

N,N-Dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon c...

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Main Authors: Hsu, Bryan Boen (Contributor), Wong, Sze Yinn (Contributor), Chen, Jianzhu (Contributor), Klibanov, Alexander M. (Contributor), Hammond, Paula T (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hammond, Paula T. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-07-28T15:24:50Z.
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