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|a Hsu, Bryan Boen
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|a Massachusetts Institute of Technology. Department of Biological Engineering
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|a Massachusetts Institute of Technology. Department of Biology
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
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|a Massachusetts Institute of Technology. Department of Chemistry
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Klibanov, Alexander M.
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|a Klibanov, Alexander M.
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|a Wong, Sze Yinn
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|a Hammond, Paula T.
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|a Chen, Jianzhu
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|a Hsu, Bryan Boen
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|a Wong, Sze Yinn
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|a Chen, Jianzhu
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|a Klibanov, Alexander M.
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|a Hammond, Paula T
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|a Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations
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|b National Academy of Sciences (U.S.),
|c 2011-07-28T15:24:50Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/64967
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|a N,N-Dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human and avian, both wild-type and drug-resistant, strains) irreversibly adhere to it, followed by structural damage and inactivation; subsequently, viral RNA is released into solution, while proteins remain adsorbed.
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|a MIT/Army Institute for Soldier Nanotechnologies (contract DAAD-19-02-D0002)
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|a United States. Army Research Office
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|a en_US
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|a Article
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|t Proceedings of the National Academy of Sciences of the United States of America
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