Effect of photobleaching on calibration model development in biological Raman spectroscopy

A major challenge in performing quantitative biological studies using Raman spectroscopy lies in overcoming the influence of the dominant sample fluorescence background. Moreover, the prediction accuracy of a calibration model can be severely compromised by the quenching of the endogenous fluorophor...

Full description

Bibliographic Details
Main Authors: Barman, Ishan (Contributor), Kong, Chae-Ryon (Contributor), Singh, Gajendra P. (Author), Dasari, Ramachandra Rao (Contributor)
Other Authors: Massachusetts Institute of Technology. Laser Biomedical Research Center (Contributor), Massachusetts Institute of Technology. Spectroscopy Laboratory (Contributor)
Format: Article
Language:English
Published: Society of Photo-optical Instrumentation Engineers (SPIE), 2011-07-28T15:46:43Z.
Subjects:
Online Access:Get fulltext