Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

Pulse-modulated second harmonic imaging microscope quantitatively demonstrates marked increase of collagen in tumor after chemotherapy

Pulse-modulated second harmonic imaging microscopes (PM-SHIMs) exhibit improved signal-to-noise ratio (SNR) over conventional SHIMs on sensitive imaging and quantification of weak collagen signals inside tissues. We quantify the spatial distribution of sparse collagen inside a xenograft model of hum...

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Main Authors: Raja, Anju M. (Author), Xu, Shuoyu (Author), Sun, Wanxin (Author), Zhou, Jianbiao (Author), Tai, Dean C. S. (Author), Chen, Chien Shing (Author), Rajapakse, Jagath (Contributor), So, Peter T. C. (Contributor), Yu, Hanry (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Society of Photo-optical Instrumentation Engineers, 2011-07-28T16:19:08Z.
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