Error and Error Mitigation in Low-Coverage Genome Assemblies

The recent release of twenty-two new genome sequences has dramatically increased the data available for mammalian comparative genomics, but twenty of these new sequences are currently limited to ~2× coverage. Here we examine the extent of sequencing error in these 2× assemblies, and its potential im...

Full description

Bibliographic Details
Main Authors: Hubisz, Melissa J. (Author), Lin, Michael F. (Author), Kellis, Manolis (Contributor), Siepel, Adam (Author)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-08-26T15:59:48Z.
Subjects:
Online Access:Get fulltext