Rag proteins regulate amino-acid-induced mTORC1 signalling

Rag proteins regulate amino-acid-induced mTORC1 signalling

The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPa...

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Bibliographic Details
Main Authors: Sancak, Yasemin (Contributor), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Biomedical Society, 2011-08-31T19:25:14Z.
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Summary:The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPase) family of GTPases as mediators of amino acid signalling to mTOR is an important step towards our understanding of this mechanism.
National Institutes of Health (U.S.) (R01 CA103866)
National Institutes of Health (U.S.) (AI47389)
United States. Dept. of Defense (grant number W81XWH-07-0448)
W. M. Keck Foundation

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