Rag proteins regulate amino-acid-induced mTORC1 signalling
The serum- and nutrient-sensitive protein kinase mTOR (mammalian target of rapamycin) is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of the Rag (Ras-related GTPa...
Main Authors: | Sancak, Yasemin (Contributor), Sabatini, David (Author) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor) |
Format: | Article |
Language: | English |
Published: |
Biomedical Society,
2011-08-31T19:25:14Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
by: Bar-Peled, Liron, et al.
Published: (2014) -
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
by: Sancak, Yasemin, et al.
Published: (2012) -
Regulation of mTORC1 by amino acids
by: Bar-Peled, Liron, et al.
Published: (2017) -
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
by: Shen, Kuang, et al.
Published: (2018) -
A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
by: Bar-Peled, Liron, et al.
Published: (2014)