Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors

Introduction The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Mena expression level in primary tumors is correlated with metastasis in breast, cervical, colorectal and pancreatic cancers. Cells expressing high Mena level...

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Main Authors: Roussos, Evanthia T. (Author), Wang, Yarong (Author), Wyckoff, Jeffrey B. (Author), Sellers, Rani S. (Author), Wang, Weigang (Author), Li, Jiufeng (Author), Pollard, Jeffrey W. (Author), Gertler, Frank (Contributor), Condeelis, John S. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd., 2011-09-12T21:02:30Z.
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