Sortase-catalyzed transformations that improve the properties of cytokines

Sortase-catalyzed transformations that improve the properties of cytokines

Recombinant protein therapeutics often suffer from short circulating half-life and poor stability, necessitating multiple injections and resulting in limited shelf-life. Conjugation to polyethylene glycol chains (PEG) extends the circulatory half-life of many proteins, but the methods for attachment...

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Bibliographic Details
Main Authors: Dougan, Stephanie K. (Contributor), Chuang, Tzu-Ying (Contributor), Spooner, Eric (Contributor), Ploegh, Hidde (Contributor), Popp, Maximilian W.L (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Popp, Maximilian W. (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2011-09-16T18:06:04Z.
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