The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

The Cycad Genotoxin MAM Modulates Brain Cellular Pathways Involved in Neurodegenerative Disease and Cancer in a DNA Damage-Linked Manner

Methylazoxymethanol (MAM), the genotoxic metabolite of the cycad azoxyglucoside cycasin, induces genetic alterations in bacteria, yeast, plants, insects and mammalian cells, but adult nerve cells are thought to be unaffected. We show that the brains of adult C57BL6 wild-type mice treated with a sing...

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Main Authors: Kisby, Glen E. (Author), Fry, Rebecca C. (Contributor), Lasarev, Michael R. (Author), Bammler, Theodor K. (Author), Beyer, Richard P. (Author), Churchwell, Mona (Author), Doerge, Daniel R. (Author), Meira, Lisiane B. (Author), Palmer, Valerie S. (Author), Ramos-Crawfor (Author), Ren, Xuefeng (Author), Sullivan, Robert C. (Author), Kavanagh, Terrance J. (Author), Samson, Leona D. (Contributor), Zarbl, Helmut (Author), Spencer, Peter S. (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2011-09-19T15:11:45Z.
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