An Integrated Mathematical Model of Thrombin-, Histamine-and VEGF-Mediated Signalling in Endothelial Permeability

An Integrated Mathematical Model of Thrombin-, Histamine-and VEGF-Mediated Signalling in Endothelial Permeability

Background: Endothelial permeability is involved in injury, inflammation, diabetes and cancer. It is partly regulated by the thrombin-, histamine-, and VEGF-mediated myosin-light-chain (MLC) activation pathways. While these pathways have been investigated, questions such as temporal effects and the...

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Main Authors: Wei, X. N. (Author), Han, B. C. (Author), Zhang, J. X. (Author), Liu, X. H. (Author), Tan, C. Y. (Author), Jiang, Y. Y. (Author), Low, Boon Chuan (Contributor), Tidor, Bruce (Contributor), Chen, Yu Zong (Author)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor)
Format: Article
Language:English
Published: BioMed Central Ltd, 2011-09-21T17:34:56Z.
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