Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity

Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity

Engineered metalloproteins constitute a flexible new class of analyte-sensitive molecular imaging agents detectable by magnetic resonance imaging (MRI), but their contrast effects are generally weaker than synthetic agents. To augment the proton relaxivity of agents derived from the heme domain of c...

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Bibliographic Details
Main Authors: Lelyveld, Victor S. (Contributor), Brustad, Eric (Author), Arnold, Frances H. (Author), Jasanoff, Alan Pradip (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Nuclear Science and Engineering (Contributor)
Format: Article
Language:English
Published: American Chemical Society, 2011-10-24T15:50:52Z.
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