PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury
Acetaminophen (APAP) toxicity is the most common drug-induced cause of acute liver failure in the United States. The only available treatment, N-acetylcysteine (NAC), has a limited time window of efficacy, indicating a need for additional therapeutic options. Zebrafish have emerged as a powerful too...
Main Authors: | North, Trista E. (Author), Vedder, Lea M. (Author), Lord, Allegra M. (Author), Wishnok, John S. (Contributor), Tannenbaum, Steven Robert (Contributor), Zon, Leonard I. (Author), Goessling, Wolfram (Author), Badu, I. Ramesh (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2011-10-31T16:41:27Z.
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Subjects: | |
Online Access: | Get fulltext |
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