Both base excision repair and O-6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis

Methylating agents are widely distributed environmental carcinogens. Moreover, they are being used in cancer chemotherapy. The primary target of methylating agents is DNA, and therefore, DNA repair is the first-line barrier in defense against their toxic and carcinogenic effects. Methylating agents...

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Bibliographic Details
Main Authors: Samson, Leona D. (Contributor), Wirtz, Stefan (Author), Nagel, Georg (Author), Eshkind, Leonid (Author), Neurath, Markus F. (Author), Kaina, Bernd (Author)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Oxford University Press, 2011-11-02T17:43:49Z.
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