Proteins Modified by the Lipid Peroxidation Aldehyde 9,12-Dioxo-10(E)-dodecenoic Acid in MCF7 Breast Cancer Cells

Proteins Modified by the Lipid Peroxidation Aldehyde 9,12-Dioxo-10(E)-dodecenoic Acid in MCF7 Breast Cancer Cells

The hydroperoxide of linoleic acid (13-HPODE) degrades to 9,12-dioxo-10(E)-dodecenoic acid (DODE), which readily modifies proteins. This study identified the major proteins in MCF7 cells modified by DODE. To reduce false positives, three methods were used to identify DODE-modified proteins. First, c...

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Bibliographic Details
Main Authors: Slade, Peter G. (Contributor), Williams, Michelle V. (Contributor), Brahmbhatt, Viral (Contributor), Wishnok, John S. (Contributor), Dash, Ajit (Contributor), Tannenbaum, Steven Robert (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Tannenbaum, Steven R. (Contributor)
Format: Article
Language:English
Published: American Chemical Society, 2011-11-02T20:21:05Z.
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