Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models

Compounds from an Unbiased Chemical Screen Reverse Both Er-to-Golgi Trafficking Defects and Mitochondrial Dysfunction in Parkinson's Disease Models

α-Synuclein (α-syn) is a small lipid-binding protein involved in vesicle trafficking whose function is poorly characterized. It is of great interest to human biology and medicine because α-syn dysfunction is associated with several neurodegenerative disorders, including Parkinson's disease (PD)...

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Main Authors: Su, Linhui Julie (Contributor), Auluck, Pavan K. (Contributor), Outeiro, Tiago Fleming (Contributor), Yeger-Lotem, Esti (Contributor), Kritzer, Joshua A. (Contributor), Tardiff, Daniel F. (Contributor), Bell, George W. (Contributor), Fraenkel, Ernest (Contributor), Lindquist, Susan (Contributor), Strathearn, Katherine E. (Author), Liu, Fang (Author), Cao, Songsong (Author), Hamamichi, Shusei (Author), Hill, Kathryn J. (Author), Caldwell, Kim A. (Author), Cooper, Antony A. (Author), Caldwell, Guy A. (Author), McCaffery, J. Michael (Author), Rochet, Jean-Christophe (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Company of Biologists Limited, 2011-11-03T17:49:00Z.
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